ln -s /media/Data/.wine ~/.wine

wine: /media/Data/.wine is not owned by you

# adduser wine

gpasswd -a username wine

#
# This file MUST be edited with the 'visudo' command as root.
#

# Host alias specification

# User alias specification

# Cmnd alias specification
Cmnd_Alias WINE = /usr/bin/wine, /usr/bin/wine32, /usr/bin/wine-auto,\
                  /usr/bin/wineboot, /usr/bin/wineboot32, /usr/bin/winecfg,\
                  /usr/bin/winecfg32, /usr/bin/wineconsole,\
                  /usr/bin/wineconsole32, /usr/bin/winedbg, /usr/bin/winedbg32,\
                  /usr/bin/winefile, /usr/bin/winefile32,\
                  /usr/bin/wine-font-convert, /usr/bin/wine-font-convert32,\
                  /usr/bin/winemine, /usr/bin/winemine32,\
                  /usr/bin/winepath, /usr/bin/winepath32,\
                  /usr/bin/wine-safe
# User privilege specification

# Allow members of group sudo to execute any command
%wine ALL = (wine) WINE

ln -s /media/Data/.wine /home/wine/.wine

$ sudo -u wine wine regedit
No protocol specified
No protocol specified
No protocol specified
No protocol specified
err:winediag:SECUR32_initNTLMSP ntlm_auth was not found or is outdated. Make sure that ntlm_auth >= 3.0.25 is in your path. Usually, you can find it in the winbind package of your distribution.
fixme:heap:HeapSetInformation (nil) 1 (nil) 0
No protocol specified
No protocol specified
Application tried to create a window, but no driver could be loaded.
Make sure that your X server is running and that $DISPLAY is set correctly.
err:systray:initialize_systray Could not create tray window
fixme:ole:CoInitializeSecurity ((nil),-1,(nil),(nil),0,3,(nil),0,(nil)) - stub!
No protocol specified
No protocol specified
No protocol specified
No protocol specified
Application tried to create a window, but no driver could be loaded.
Make sure that your X server is running and that $DISPLAY is set correctly.

xhost +SI:localuser:wine

#!/bin/sh

WINEGROUP=wine
WINEUSER=wine
WINEDIR=/home/$WINEUSER/.wine

if [ '`groups | grep $WINEGROUP`' ]; then

  if [ "$DISPLAY" ]; then
    if ! [ '`xhost | grep $WINEUSER`' ]; then
      xhost "SI:localuser:$WINEUSER"
    fi
  fi

  sudo -u "$WINEUSER" wine "$@"
  
fi

exit 0